Career CategoryOperationsJob DescriptionJoin Amgen’s Mission of Serving PatientsAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.Manager Manufacturing Solution Prep - NightsWhat you will doLet’s do this. Let’s change the world. In this vital role you will champion a safe and compliant production environment through structured on-the-floor presence. This role will also be well positioned to champion problem solving and continuous improvement among the team and in collaboration with cross-functional partners in Quality, EHSS, F&E, and Process Development. The manager will be an active player in our OnePlant operating model, building reliability, agility, and efficiency through our I-530 pathway and Agile Workforce.The Front-Line Manager will collaborate routinely with Quality Assurance, Quality Control, Engineering, Facilities and Engineering, Maintenance, Process Development, Process Engineering, Supply Chain, Regulatory Compliance, and other site functions. This role requires strong technical ownership of manufacturing operations, disciplined execution of cGMP and safety expectations, and the ability to make timely decisions in a dynamic production environment.With minimal direction, the Manager is responsible for leading on-the-floor operations and staff in manufacturing. The Manager will supervise, coach, hire, onboard, and develop manufacturing staff while ensuring that team members are trained, capable, engaged, and prepared to meet production requirements. The Front-Line Manager will help define area objectives, identify improvement opportunities, lead change efforts, and deliver against short- and long-term AR5 manufacturing goals.This leader will be expected to strengthen reliability, improve operational efficiency, enable agility for future business needs, and support AR5’s commitment to being the best place for talent.The on-boarding phase for this role will last 2-6 weeks, during which time successful incumbents will be on an administrative schedule (Monday through Friday, approximately 8am to 5pm). Following the on-boarding phase, the successful incumbent will be expected to join a shift team working a 12-hour shift. The shift pattern will be 7pm -7am (C or D shift) with a two-week rotation covering 7 days per week. The rotating shift offers several benefits such as, an average of 14 days on shift per month with every other weekend off and 15% shift differential.Scope of Responsibilities:Safety and Quality Oversight: The cornerstone of our operations are safe and compliant execution by the manufacturing team - own and reinforce the strong safety and quality culture within the shift and ensure standards are upheld through active engagement and coaching.Operational Leadership: Lead the shift and collaborate with peer managers to reliably deliver production targets. Coordinate daily task allocation and plan ahead with the scheduling team for short- to mid-term schedule needs. Provide Purposeful Presence on the Floor (Gemba) to monitor overall department performance, provide coaching, and ensure consistency with our core Floor Operating Principles. Coordinate with support functions to troubleshoot, identify and resolve issues as needed while on shift.Talent Development: Mentor and develop talent, fostering an environment of engagement, belonging, continuous learning, and operational excellence. Build a high-performing team, ensuring accountability and advancing technical and leadership capabilities.Continuous Improvement, Innovation, and Process Enhancement: Identify and drive process improvement initiatives to support higher efficiency and eliminate non-value-added activities.Agile Workforce Leadership: Role model ARI Manufacturing’s Agile Workforce behaviors by planning and executing cross-training and dynamic resource allocation across AR5 and AR30 that enhances responsiveness and productivity while increasing opportunities for staff development.Leading Strategy Development and ExecutionAssist in developing and implementing departmental strategy and plans aligned with broader AR5, ARI, and site manufacturing objectives.Translate strategic priorities into clear daily, weekly, and shift-level execution plans.Anticipate operational, quality, safety, training, and schedule risks and build contingencies to reduce impact.Deliver strong business results through continuous improvement, standardization, and disciplined execution.Use metrics, audit outcomes, process data, and staff feedback to identify trends and improve performance.Lead change efforts that improve safety, compliance, quality, efficiency, throughput, and reliability.Ensure the team understands how daily execution connects to Amgen’s mission, patient impact, and AR5 business priorities.Building a Strong Organizational AlignmentBe responsible for selection, onboarding, training, evaluation, staff relations, performance management, and development of manufacturing staff.Ensure the right people, skills, and resources are in place and optimally allocated to achieve production, quality, and business goals.Interact with management to optimize organizational structure, roles, responsibilities, and shift performance.Build and develop a diverse, impactful team that can reliably execute complex manufacturing operations.Work across functions to build organizational and individual capability.Develop strong relationships with staff members and provide open, clear, and actionable feedback.Foster a team environment that supports accountability, innovation, continuous improvement, learning, knowledge-sharing, and psychological safety.Promote clear communication across shifts to ensure continuity, alignment, and readiness.Lead with a people-centered approach that supports engagement, retention, empowerment, and development.What we expect of youWe are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a motivated professional with these qualifications.Basic Qualifications:High school diploma / GED and 12 years of Manufacturing and Operations experience ORAssociate’s degree and 10 years of Manufacturing and Operations experience ORBachelor’s degree and 5 years of Manufacturing and Operations experience ORMaster’s degree and 3 years of Manufacturing and Operations experience ORDoctorate degreeIn addition to meeting at least one of the above requirements, you must have experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources. Your managerial experience may run concurrently with the required technical experience referenced abovePreferred Qualifications:Background in Life Sciences or EngineeringKnowledge and experience within a cGMP or other highly regulated environment including a basic understanding of technical elements across engineering, biological or chemical processingSkilled in change management, team building, and fostering innovationExcellent communication skills, drive, sense of urgency, and analytical problem-solving abilitiesDemonstrated experience in applying Operational Excellence and Lean ManufacturingExperience with performance management including coaching, conflict resolution and performance reviewsAbility to be flexible and manage changeDemonstrated ability to forge and maintain strong relationships with other functional areasUser-level fluency with digital tools for daily management, data analysis and visualization, and application of Artificial Intelligence (e.g, Copilot, Chat GPT, etc)What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models, including remote and hybrid work arrangements, where possibleApply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.SponsorshipSponsorship for this role is not guaranteed.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation..Salary Range106,148.00USD -143,612.00 USD