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Postdoctoral Fellow-Discovery Protein Science

Amgen

Postdoctoral Fellow-Discovery Protein Science

full-timePosted: Jul 29, 2026Updated: Aug 28, 2026US - California - South San Francisco

Job Description

Career CategoryPostdoctoralJob DescriptionJob DescriptionJoin Amgen’s Mission of Serving PatientsAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.Postdoctoral Fellow-Discovery Protein ScienceWhat you will doLet’s do this! Let’s change the world.The integrative Protein Generation and Protein Design groups within Discovery Protein Science are seeking a highly motivated and creative scientist to develop impactful platforms toward advancing new therapeutic hypotheses. In this vital role, you will apply interdisciplinary approaches to develop methodologies for autoantigen profiling, with implications for target identification and biomarker discovery. This is a 4-year fellowship within Amgen’s Research & Development Postdoc Program, which is dedicated to training the next generation of biomedical scientists. This is an onsite laboratory position at our South San Francisco site. To support your research, you will have access to state-of-the art molecular biology, protein design, protein expression, protein biochemistry, and flow cytometry capabilities. Responsibilities:As a Postdoctoral Fellow, you will:Construct and validate protein libraries for autoantigen profiling Apply generated libraries to profile the binding of complex mixtures of antibodiesInteract and collaborate with scientists cross-functionally, gaining broad exposure to the process of drug discoveryMake novel discoveries that contribute to the broader field, disseminating scientific contributions through impactful publications and conference presentationsWhat we expect of youWe are all different, yet we all use our unique contributions to serve patients. The Postdoctoral Fellow we seek is a professional with these qualifications.Basic qualificationsPhD at the time of appointment in molecular biology, chemical biology, biochemistry, or related life sciences disciplinesPreferred qualificationsDemonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first-author publication(s)Proven experience in sequence and structure-based construct design to improve protein expression and high-efficiency cloning methodsExperience with protein library construction, mammalian cell culture, flow cytometry, and NGS analysis workflows is a plusExcellent critical thinking, organizational, and communication skillsPassion to learn and work collaboratively within a large team of scientists with diverse technical and cultural backgroundsWhat you can expect from usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is $100,000.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.SponsorshipSponsorship for this role is not guaranteed.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.Salary Range85,238.00USD -115,322.00 USD

Locations

  • US - California - South San Francisco

Skills Required

  • sequenceintermediate
  • protein library constructionintermediate

Required Qualifications

  • PhD at the time of appointment in molecular biology, chemical biology, biochemistry, or related life sciences disciplines (degree in molecular biology)

Preferred Qualifications

  • Demonstration of independent design, execution, and interpretation of experiments and results, as exemplified by a solid publication record with first-author publication(s) (experience)
  • Proven experience in sequence and structure-based construct design to improve protein expression and high-efficiency cloning methods (experience)
  • Experience with protein library construction, mammalian cell culture, flow cytometry, and NGS analysis workflows is a plus (experience)
  • Excellent critical thinking, organizational, and communication skills (experience)
  • Passion to learn and work collaboratively within a large team of scientists with diverse technical and cultural backgrounds (experience)

Responsibilities

  • Let’s do this! Let’s change the world.
  • The integrative Protein Generation and Protein Design groups within Discovery Protein Science are seeking a highly motivated and creative scientist to develop impactful platforms toward advancing new therapeutic hypotheses. In this vital role, you will apply interdisciplinary approaches to develop methodologies for autoantigen profiling, with implications for target identification and biomarker discovery.
  • This is a 4-year fellowship within Amgen’s Research & Development Postdoc Program, which is dedicated to training the next generation of biomedical scientists. This is an onsite laboratory position at our South San Francisco site. To support your research, you will have access to state-of-the art molecular biology, protein design, protein expression, protein biochemistry, and flow cytometry capabilities.
  • Construct and validate protein libraries for autoantigen profiling
  • Apply generated libraries to profile the binding of complex mixtures of antibodies
  • Interact and collaborate with scientists cross-functionally, gaining broad exposure to the process of drug discovery
  • Make novel discoveries that contribute to the broader field, disseminating scientific contributions through impactful publications and conference presentations

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