Career CategoryInformation SystemsJob DescriptionJoin our team at AMGEN Capability Center Portugal, consistently recognized among the top companies in the Best Workplaces™ ranking by Great Place to Work® in Portugal. In 2026, we were once again distinguished as one of the top Best Workplaces in the country (category 201–500 employees), reinforcing our commitment to an exceptional employee experience and workplace culture.We are a team of over 500 talented individuals, spanning more than 30 functions and areas of expertise, and representing over 40 nationalities. Together, we bring diverse perspectives and professional backgrounds to help shape the future of healthcare through innovation and technology.This is your opportunity to explore a world of possibilities across areas such as Data & Analytics, Digital, Technology & Innovation, Cybersecurity, R&D Operations, Global Distribution, Finance, Regulatory Affairs, General & Administrative, Human Resources, and many more.Located in the heart of Lisbon, our AMGEN office fosters a culture of innovation, excellence, and purpose. Come thrive with us at AMGEN, supporting our mission To Serve Patients.What we do at AMGEN matters in people’s lives.Principal IS Business System Analyst – Real World EvidenceLIVEWHAT YOU WILL DOAmgen is seeking a Principal Business Analyst to join the Real World Evidence (RWE) Product Team.As a Principal IS Business Systems Analyst at Amgen, you will provide strategic leadership and guidance in analyzing business requirements and designing information systems solutions. You will collaborate with stakeholders to understand business needs, identify system enhancements, and drive system implementation projects. Your extensive experience in business analysis, system design, and project management will enable you to deliver innovative and effective solutions that align with the company's strategic goals.Roles & Responsibilities: Collaborate with System Architects and Product Managers to manage business analysis activities, ensuring alignment with engineering and product goals Capture the voice of the customer to define business processes and product needs Work with Product Managers and customers to define scope and value for new developments Collaborate with Engineering and Product Management to prioritize release scopes and refine the Product backlog Ensure non-functional requirements are included and prioritized in the Product and Release Backlogs Facilitate the breakdown of Epics into Features and Sprint-Sized User Stories and participate in backlog reviews with the development team Clearly express features in User Stories/requirements so all team members and stakeholders understand how they fit into the product backlog Translate complex business and technological needs into clear, actionable requirements for development teams Ensure Acceptance Criteria and Definition of Done are well-defined Stay focused on software development to ensure it meets requirements, providing proactive feedback to stakeholders Develop and execute effective product demonstrations for internal and external stakeholders Maintain accurate documentation of configurations, processes, and changes Serve as a liaison between global DTI functional areas and business clients, prioritizing their needs and expectations Manage a suite of custom internal platforms, commercial off-the-shelf (COTS) software, and systems integrations WINWHAT WE EXPECT OF YOUBasic Qualifications and Experience: Master’s degree with 8 - 10 years of experience in Life Science/Biotechnology/Pharmacology/Information Systems experience OR Bachelor’s degree with 10 - 14 years of experience in Life Science/Biotechnology/Pharmacology/Information Systems experience OR Diploma with 14 - 18 years of experience in Life Science/Biotechnology/Pharmacology/Information Systems experience Must-Have Skills: Excellent problem-solving skills and a passion for tackling complex challenges in drug discovery with technology Experience with Agile software development methodologies (Scrum) Excellent communication skills and the ability to interface with senior leadership with confidence and clarity Has experience with writing user requirements and acceptance criteria in agile project management systems such as JIRA Demonstrated expertise in a clinical development domain and related technology needsGood-to-Have Skills: Experience in managing product features for PI planning and developing product roadmaps and user journeys Technical thought leadership Able to communicate technical or complex subject matters in business terms Jira Align experience Knowledge of Cloud technologies and GCP validationExperience of DevOps, Continuous Integration, and Continuous Delivery methodology Professional Certifications:SAFe for Teams certification (preferred) Soft Skills: Able to work under minimal supervision Skilled in providing oversight and mentoring team members. Demonstrated ability in effectively delegating work Excellent analytical and gap/fit assessment skills Strong verbal and written communication skills Ability to work effectively with global, virtual teams High degree of initiative and self-motivation Ability to manage multiple priorities successfully Team-oriented, with a focus on achieving team goals Strong presentation and public speaking skills Shift Information:This position requires you to work a later shift and may be assigned a second or third shift schedule. Candidates must be willing and able to work during evening or night shifts, as required based on business requirements.THRIVEWHAT YOU CAN EXPECT OF USVast opportunities to learn, develop, and move up and across our global organization.Diverse and inclusive community of belonging, where colleagues are empowered to bring ideas to the table, take risks, and act.Generous AMGEN Total Rewards Plan comprising healthcare, finance, wealth, and career benefits.Flexible work arrangements.APPLY NOWObjects in your future are closer than they appear. Join us.CAREERS.AMGEN.COMEQUAL OPPORTUNITY STATEMENTAMGEN is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform crucial job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation..Salary Range70,664.75 EUR - 95,605.25 EUR