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Target Validation Sr Director

Amgen

Target Validation Sr Director

full-timePosted: Jul 29, 2026Updated: Aug 28, 2026US - California - South San Francisco

Job Description

Career CategoryResearchJob DescriptionJoin Amgen’s Mission of Serving PatientsAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.Target Validation Sr DirectorWhat you will doLet’s do this. Let’s change the world. In this vital role as Senior Director, Global Research – Target Discovery you will have the opportunity to shape and lead Amgen’s Target Validation Unit within Research Biology.This research based Senior Director role will be responsible for building, leading and developing a multidisciplinary team that implements the most cutting-edge experimental and computational science and technologies to address and solve complex biological problems related to target discovery for multiple therapeutic areas.Responsibilities Lead and develop a multidisciplinary organization of ~25 scientists within Research BiologyIntegrate diverse experimental disciplines and workflows to ensure coordinated execution and efficient delivery of novel molecular insightsEstablish platform priorities, resource allocation, and capacity planning in alignment with Research Biology and Therapeutic Area prioritiesDefine clear roles, responsibilities, and seamless handoffs across teams and partnering organizationsDrive adoption of automated experimental workflows, and integration of AI/ML to enable efficient experimentation across programsServe as a senior scientific partner to Target Discovery and Therapeutic AreasSet clear expectations and enable scientists with diverse skill sets to collaborate effectively and contribute to early research pipelineServe as a core member of Target Discovery Advisory Forum, and play a key role in target discovery, validation and prioritization. Engage, influence, and align therapeutic area stakeholders.Guide team members in synthesizing and communicating complex scientific and data-driven insights to key stakeholders and advisory forum.Contribute to fostering a highly collaborative, creative, dynamic and cutting-edge research environmentWhat we expect of youWe are all different, yet we all use our unique contributions to serve patients. The candidate we seek is an experienced scientific leader with the following qualifications.Basic Qualifications:Doctorate degree PhD in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant discipline and 7 years of scientific leadership experience in biotech, pharma or equivalent research environmentsORMaster’s degree in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant discipline and 10 years of scientific leadership experience in biotech, pharma or equivalent research environmentsORBachelor’s degree in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant disciplineand 12 years of scientific leadership experience in biotech, pharma or equivalent research environmentsPreferred Qualifications:Experience leading mechanistic discovery research programs and -omics platforms.Demonstrated ability to integrate experimental science with enterprise data, analytics, or AI/ML capabilities.Appreciation for and experience with application of genetics, genomics, transcriptomics, proteomics, structural and AI/ML approaches to biological research.Proven track record of scientific impact in molecular, biochemical and cell biological characterization, evidenced by publications in top-tier journals, patents, and program advancement.Recognized scientific excellence, passion for discovery research and productivityExperience managing budgets and capital investmentsDemonstrated success in identifying, attracting, and retaining scientific talent.Proven mentorship and team development experience.Strength in team building.Clear and compelling communicator.What you can expect of usAs we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.The annual base salary range for this opportunity in the U.S. is $265,405 - $312,459.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accountsA discretionary annual bonus program, or for field sales representatives, a sales-based incentive planStock-based long-term incentivesAward-winning time-off plansFlexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.Apply now and make a lasting impact with the Amgen team.careers.amgen.comIn any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.Application deadlineAmgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.SponsorshipSponsorship for this role is not guaranteed.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.Salary RangeUSD - USD

Locations

  • US - California - South San Francisco

Salary

265,405 - 312,459 USD / yearly

Skills Required

  • biotechintermediate
  • application of geneticsintermediate

Required Qualifications

  • Doctorate degree PhD in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant discipline and 7 years of scientific leadership experience in biotech, pharma or equivalent research environments (experience, 7 years)
  • Master’s degree in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant discipline and 10 years of scientific leadership experience in biotech, pharma or equivalent research environments (experience, 10 years)
  • Bachelor’s degree in biochemistry, cell biology, molecular biology, computational biology, immunology, oncology, metabolism or a relevant disciplineand 12 years of scientific leadership experience in biotech, pharma or equivalent research environments (experience, 12 years)

Preferred Qualifications

  • Experience leading mechanistic discovery research programs and -omics platforms. (experience)
  • Demonstrated ability to integrate experimental science with enterprise data, analytics, or AI/ML capabilities. (experience)
  • Appreciation for and experience with application of genetics, genomics, transcriptomics, proteomics, structural and AI/ML approaches to biological research. (experience)
  • Proven track record of scientific impact in molecular, biochemical and cell biological characterization, evidenced by publications in top-tier journals, patents, and program advancement. (experience)
  • Recognized scientific excellence, passion for discovery research and productivity (experience)
  • Experience managing budgets and capital investments (experience)
  • Demonstrated success in identifying, attracting, and retaining scientific talent. (experience)
  • Proven mentorship and team development experience. (experience)
  • Strength in team building. (experience)
  • Clear and compelling communicator. (experience)

Responsibilities

  • Let’s do this. Let’s change the world. In this vital role as Senior Director, Global Research – Target Discovery you will have the opportunity to shape and lead Amgen’s Target Validation Unit within Research Biology.
  • This research based Senior Director role will be responsible for building, leading and developing a multidisciplinary team that implements the most cutting-edge experimental and computational science and technologies to address and solve complex biological problems related to target discovery for multiple therapeutic areas.
  • Lead and develop a multidisciplinary organization of ~25 scientists within Research Biology
  • Integrate diverse experimental disciplines and workflows to ensure coordinated execution and efficient delivery of novel molecular insights
  • Establish platform priorities, resource allocation, and capacity planning in alignment with Research Biology and Therapeutic Area priorities
  • Define clear roles, responsibilities, and seamless handoffs across teams and partnering organizations
  • Drive adoption of automated experimental workflows, and integration of AI/ML to enable efficient experimentation across programs
  • Serve as a senior scientific partner to Target Discovery and Therapeutic Areas
  • Set clear expectations and enable scientists with diverse skill sets to collaborate effectively and contribute to early research pipeline
  • Serve as a core member of Target Discovery Advisory Forum, and play a key role in target discovery, validation and prioritization. Engage, influence, and align therapeutic area stakeholders.
  • Guide team members in synthesizing and communicating complex scientific and data-driven insights to key stakeholders and advisory forum.
  • Contribute to fostering a highly collaborative, creative, dynamic and cutting-edge research environment

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