At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. About the TeamAt Eli Lilly and Company, our Global Pharmacokinetics/Pharmacodynamics and Pharmacometrics (PMx) team is dedicated to advancing the discovery and development of innovative medicines through interdisciplinary collaboration and the application of cutting-edge quantitative science and technology. Our vision is to be leaders in model-informed drug discovery, development, and decision-making, cultivating a community of exceptional scientists who transform insight into impact, improving global health.The PMx team operates across all phases of drug development and serves as a strategic scientific partner to project teams, regulatory functions, and senior leadership. We are currently investing in automation, AI/ML integration, and standardized modeling workflows to accelerate timelines and expand our impact.Role OverviewThis role is designed for a scientist ready to operate as an enterprise-level scientific leader. The Director/Sr Director Pharmacometrics is expected to define which scientific problems matter (not just to solve them) and to shape PMx strategy across programs, platforms, and the broader organization. This is a high-visibility role with direct influence on drug development decisions, regulatory interactions, and team capability-building.You will serve as a trusted scientific partner whose input is actively sought by cross-functional leaders, PKPD colleagues, and senior partners. Your impact will extend well beyond the immediate project portfolio.Key ResponsibilitiesScientific & Technical LeadershipChampion MIDD approaches across programs and platforms, defining and delivering novel PMx strategies that shape drug development decisions.Resolve complex technical and scientific challenges with cross-program impact, contributing to exposure-response, dose justification, and regulatory submission strategies in collaboration with PKPD lead and across functions.Engage proactively with regulatory agencies through meetings, responses, and advisory interactions.Partnership & People DevelopmentInspire and elevate the scientists around you through scientific leadership, mentorship, and good examples.Mentor scientists at all levels, building technical depth, scientific judgment, and confidence in others as a natural extension of how you work.Create the conditions for others to succeed: share knowledge generously, open doors, and actively invest in bench strength and organizational capability.Automation, Innovation & AI IntegrationChampion adoption of automation tools and AI/ML approaches that deliver pragmatic, scalable value across the department and beyond.External Visibility & Scientific LeadershipBuild PMx’s external reputation through publications and scientific leadership in industry and regulatory forums.Communicate complex science with executive presence to diverse audiences, from project teams to senior leadership.Basic QualificationsPhD in a relevant scientific field such as PMx, biological/pharmaceutical sciences, bioengineering, biostatistics, computer science/engineering, data science, or a related discipline. with 5 years post PhD experienceExperience in population PKPD modeling, across multiple programs or development phases.Experince in NONMEM and/or Monolix, and R.Additional Skills & PreferencesExperience with mrgsolve, Julia, Phoenix NLME, and/or MATLAB is highly valued.Demonstrated ability to translate quantitative modeling outputs into clear scientific and regulatory narratives for cross-functional and non-specialist audiences.Proven track record of influencing drug development decisions and regulatory strategy through PMx analyses, with evidence of impact beyond a single project.MIDD Experience shaping technical strategy across programs or platforms, including involvement in regulatory submissions, health authority interactions, or cross-functional governance bodies.Strong mentorship and coaching skills, with experience developing the capabilities of more junior scientists.Active engagement with AI and automation in a PMx context, including hands-on experience with tools, a genuine curiosity for what's possible, and the judgment to translate innovation into practical scientific value. We are in the middle of a transformation, and this person will help lead it.Strong organizational and self-management skills, with the ability to manage a complex portfolio and prioritize for maximum scientific impact.Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is$177,000 - $308,000Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLilly