At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. This position starts with a 12-month contract, with the intention of offering a permanent contract based on mutual fit. (Dienstverband: tijdelijk met uitzicht op vast)Role OverviewWe are hiring for two Sr. Principal Engineer (Process Engineering) positions at a brand-new pharmaceutical manufacturing site being built in the Netherlands. Both roles carry the same responsibilities and team structure — the distinction is process specialism:Variant 1 — Oral Solid Dosage (OSD): direct compression, coating. SDD experience a plus.Variant 2 — Spray-Dried Dispersion (SDD): spray drying, amorphous solid dispersion, polymer/solvent systems, solvent handling at scale. Broader OSD experience a strong plus.Please indicate your primary process focus when applying.What You'll Be DoingProcess DesignDefine manufacturing processes at scale, providing technical input into equipment selection, process flows, and plant layoutTranslate high-level design concepts into practical solutions during the detailed design phaseEnsure process designs align with safety requirements, scalability, efficiency, and long-term operabilityIdentify and resolve process design gaps before they become operational problemsTechnical ExpertiseAct as subject matter expert for your process area (OSD or SDD)Guide technical decisions on process feasibility, material handling, solvent controls, and equipment specificationAuthor and review technical documents including URS, design documents, change controls, and deviation investigationsApply structured problem-solving tools including FMEA, HAZOP, SPC, DoE, and RCACommissioning & QualificationSupport process validation and C&Q strategy for your process area, including IQ, OQ, and PQ executionDefine and manage the AQM/AQbD strategy for the processSupport FAT and SAT activities with equipment vendorsProvide on-call technical support during commissioning and early operationsCross-functional CollaborationPartner with Quality, EHS, Manufacturing Operations, and MSAT to align process design with compliance requirementsInterface with the Engineering Technical Centre, external vendors, and project stakeholdersWork closely with automation and maintenance teams throughout design and build phasesCoaching & DevelopmentMentor junior process engineers as the site team growsContribute to technical screening and interview panelsChampion engineering best practice and technical standards across the siteBasic RequirementsBachelor's degree in Chemical or Mechanical Engineering, or equivalent6–8+ years in pharmaceutical process engineering at senior individual contributor levelHands-on experience in the relevant process area (OSD or SDD — see variants above)Solvent-handling experience essential for SDD variantWorking knowledge of EU GMP (EudraLex Volume 4), ICH Q7–Q10, GDP, and pharmaceutical quality systemsPractical experience with FMEA, SPC, HAZOP, RCA, and GMP documentation (change controls, deviation investigations, protocols)Professional fluency in EnglishBased on-site full-time in the Netherlands; 24/7 availability during commissioningAdditional Preferred SkillsMaster's degree in Chemical, Pharmaceutical, or Process EngineeringPrior experience on a greenfield site, plant start-up, or major capital projectATEX/DSEAR knowledge (particularly relevant for SDD solvent-handling operations)Exposure to PAT, MES, and automated/paperless manufacturing environmentsLean/Six Sigma Green Belt or Black BeltDutch language (conversational or above)Track record of mentoring and developing junior engineersAdditional InformationRelocation support is available for candidates based outside the Netherlands. Occasional travel required for vendor visits, sister-site collaboration, and project meetings.Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively "Lilly") are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.#WeAreLillyLilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is €67,500 - €121,000Full-time equivalent employees may also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a pension plan; vacation benefits; eligibility for healthcare benefits; flexible benefits (if applicable) life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLilly