Senior Scientist | Formulation & Nucleic Acid Delivery Development
Thermo Fisher Scientific
Senior Scientist | Formulation & Nucleic Acid Delivery Development
Job Description
Work ScheduleStandard (Mon-Fri)Environmental ConditionsSome degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)Job DescriptionAbout Thermo Fisher ScientificAt Thermo Fisher Scientific, we develop solutions that help people live healthier, cleaner, and safer lives. This is more than our mission — it is the impact our colleagues make every day.At our Vilnius site, we develop and manufacture innovative life science and diagnostic technologies used by researchers, clinicians, and laboratories around the world. Our teams work in an international scientific environment where formulation science, chemistry, analytics, biology, product development, and manufacturing come together to create products that support customers globally.Join a team where formulation development, scientific problem-solving, and collaboration help advance next-generation nucleic acid delivery technologies.Job OverviewWe are looking for a Senior Scientist, Formulation Scientist to support the development, optimization, and characterization of formulations for nucleic acid delivery reagents.In this role, you will work with lipid- and nanoparticle-based delivery systems, helping advance research and product development programs from early-stage concepts through technology transfer. You will design and execute formulation studies, generate high-quality scientific data, and support the development of robust, scalable formulations.This role is a strong fit for a scientist who enjoys hands-on formulation work, analytical characterization, scientific problem-solving, and cross-functional collaboration. You will work closely with R&D, Synthetic Chemistry, Analytical Development, Process Development, Manufacturing, Quality Control, Regulatory Affairs, Biology, and Program Management teams.We are looking for someone curious, proactive, team-oriented, and comfortable working in a global, multidisciplinary environment. Strong communication, verbal presentation skills, and the ability to collaborate across teams are important for success in this role.Key ResponsibilitiesDesign, develop, optimize, and characterize formulations for nucleic acid delivery systems, including lipid- and nanoparticle-based platformsPartner with R&D scientists to translate novel delivery concepts into robust, scalable formulationsDesign and execute formulation studies to evaluate critical quality attributes, including particle size, encapsulation efficiency, stability, physicochemical properties, and in vitro performanceOptimize formulation composition and manufacturing parameters to improve performance, reproducibility, scalability, and manufacturabilityCollaborate with R&D and Biology teams to correlate formulation characteristics with functional performance and support lead candidate selectionPartner with analytical scientists to establish characterization strategies and support analytical method development, qualification, and validation activitiesPerform analytical characterization using techniques such as DLS, UV-Vis spectroscopy, HPLC/UHPLC, LC-MS, and other applicable analytical technologiesContribute to stability studies, technology transfer activities, and manufacturing readiness by generating scientifically sound data and recommendationsPrepare and maintain technical documentation, including study protocols, technical reports, SOPs, electronic laboratory notebooks, and development summariesEnsure compliance with GMP, GLP where applicable, laboratory safety requirements, and data integrity principlesCollaborate effectively with cross-functional teams to achieve project milestonesMentor junior laboratory colleagues when needed and contribute to continuous improvement initiativesStay current with advances in nucleic acid delivery technologies, lipid nanoparticle formulation, analytical characterization, and pharmaceutical developmentExperience and QualificationsBachelor’s degree with 4+ years of experience or Master’s degree with 2+ years of experience in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, Materials Science, or a related scientific fieldExperience in formulation development and characterization of drug delivery systems, nanoparticles, lipid-based formulations, or other complex pharmaceutical formulationsExperience supporting R&D programs through formulation development, technology optimization, and cross-functional scientific collaborationExperience with analytical characterization techniques used in formulation development, such as DLS, HPLC/UHPLC, UV-Vis spectroscopy, LC-MS, or comparable methodsExperience designing and executing formulation or stability studiesStrong written and spoken English skillsSkills and CompetenciesStrong hands-on formulation and laboratory skillsAbility to analyze scientific data, interpret results, and make evidence-based recommendationsGood understanding of formulation performance, reproducibility, scalability, and manufacturabilityStrong technical writing, documentation, and organizational skillsAbility to manage multiple priorities in a fast-paced product development environmentStrong communication, collaboration, and presentation skillsAbility to work effectively across R&D, Synthetic Chemistry, Analytical Development, Process Development, Manufacturing, Quality Control, Regulatory Affairs, Biology, and Program Management teamsProactive, adaptable, and team-oriented approachCommitment to scientific excellence, innovation, and continuous learningPreferred QualificationsWorking knowledge of nucleic acid delivery technologies, including lipid nanoparticles or related delivery platformsInterest in expanding expertise in analytical method development and validation in accordance with ICH, FDA, and EMA expectationsExperience with GMP, GLP, data integrity, or regulated product development environmentsExperience supporting technology transfer, manufacturing readiness, or product development programsExperience mentoring junior laboratory personnelBroader knowledge of analytical lifecycle management or pharmaceutical developmentWhat We OfferAnnual performance bonus and additional financial benefitsComprehensive health package, including private health, life and accident insuranceWellbeing support for employees and their family members, including mental health consultations, health check-ups, vaccinations, and on-site health initiativesOpportunities for professional growth through internal training, access to Thermo Fisher e-University, and continuous developmentThe opportunity to work in a global, innovation-driven organization and collaborate with international teamsDaily benefits such as subsidized meals, gym access, and company transportationAn inclusive and supportive culture, with team events and community initiatives2 additional paid volunteering days per yearHow to ApplyIf you enjoy formulation science, hands-on laboratory work, analytical characterization, and collaborating with global teams to turn scientific ideas into scalable products, we invite you to apply.CompensationThe monthly salary range estimated for this position based in Lithuania is €2 891,67–€4 335,42.
Locations
- Lithuania, Vilnius
Skills Required
- Pharmaceutical Sciencesintermediate
- formulation developmentintermediate
- nucleic acid delivery technologiesintermediate
- analytical method developmentintermediate
- GMPintermediate
- analytical lifecycle managementintermediate
Required Qualifications
- Bachelor’s degree with 4+ years of experience or Master’s degree with 2+ years of experience in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, Materials Science, or a related scientific field (experience, 4 years)
- Experience in formulation development and characterization of drug delivery systems, nanoparticles, lipid-based formulations, or other complex pharmaceutical formulations (experience)
- Experience supporting R&D programs through formulation development, technology optimization, and cross-functional scientific collaboration (experience)
- Experience with analytical characterization techniques used in formulation development, such as DLS, HPLC/UHPLC, UV-Vis spectroscopy, LC-MS, or comparable methods (experience)
- Experience designing and executing formulation or stability studies (experience)
- Strong written and spoken English skills (experience)
- Bachelor’s degree with 4+ years of experience or Master’s degree with 2+ years of experience in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, Materials Science, or a related scientific field (experience, 4 years)
- Experience in formulation development and characterization of drug delivery systems, nanoparticles, lipid-based formulations, or other complex pharmaceutical formulations (experience)
- Experience supporting R&D programs through formulation development, technology optimization, and cross-functional scientific collaboration (experience)
- Experience with analytical characterization techniques used in formulation development, such as DLS, HPLC/UHPLC, UV-Vis spectroscopy, LC-MS, or comparable methods (experience)
- Experience designing and executing formulation or stability studies (experience)
- Strong written and spoken English skills (experience)
Preferred Qualifications
- Working knowledge of nucleic acid delivery technologies, including lipid nanoparticles or related delivery platforms (experience)
- Interest in expanding expertise in analytical method development and validation in accordance with ICH, FDA, and EMA expectations (experience)
- Experience with GMP, GLP, data integrity, or regulated product development environments (experience)
- Experience supporting technology transfer, manufacturing readiness, or product development programs (experience)
- Experience mentoring junior laboratory personnel (experience)
- Broader knowledge of analytical lifecycle management or pharmaceutical development (experience)
- Working knowledge of nucleic acid delivery technologies, including lipid nanoparticles or related delivery platforms (experience)
- Interest in expanding expertise in analytical method development and validation in accordance with ICH, FDA, and EMA expectations (experience)
- Experience with GMP, GLP, data integrity, or regulated product development environments (experience)
- Experience supporting technology transfer, manufacturing readiness, or product development programs (experience)
- Experience mentoring junior laboratory personnel (experience)
- Broader knowledge of analytical lifecycle management or pharmaceutical development (experience)
Responsibilities
- Design, develop, optimize, and characterize formulations for nucleic acid delivery systems, including lipid- and nanoparticle-based platforms
- Partner with R&D scientists to translate novel delivery concepts into robust, scalable formulations
- Design and execute formulation studies to evaluate critical quality attributes, including particle size, encapsulation efficiency, stability, physicochemical properties, and in vitro performance
- Optimize formulation composition and manufacturing parameters to improve performance, reproducibility, scalability, and manufacturability
- Collaborate with R&D and Biology teams to correlate formulation characteristics with functional performance and support lead candidate selection
- Partner with analytical scientists to establish characterization strategies and support analytical method development, qualification, and validation activities
- Perform analytical characterization using techniques such as DLS, UV-Vis spectroscopy, HPLC/UHPLC, LC-MS, and other applicable analytical technologies
- Contribute to stability studies, technology transfer activities, and manufacturing readiness by generating scientifically sound data and recommendations
- Prepare and maintain technical documentation, including study protocols, technical reports, SOPs, electronic laboratory notebooks, and development summaries
- Ensure compliance with GMP, GLP where applicable, laboratory safety requirements, and data integrity principles
- Collaborate effectively with cross-functional teams to achieve project milestones
- Mentor junior laboratory colleagues when needed and contribute to continuous improvement initiatives
- Stay current with advances in nucleic acid delivery technologies, lipid nanoparticle formulation, analytical characterization, and pharmaceutical development
- Design, develop, optimize, and characterize formulations for nucleic acid delivery systems, including lipid- and nanoparticle-based platforms
- Partner with R&D scientists to translate novel delivery concepts into robust, scalable formulations
- Design and execute formulation studies to evaluate critical quality attributes, including particle size, encapsulation efficiency, stability, physicochemical properties, and in vitro performance
- Optimize formulation composition and manufacturing parameters to improve performance, reproducibility, scalability, and manufacturability
- Collaborate with R&D and Biology teams to correlate formulation characteristics with functional performance and support lead candidate selection
- Partner with analytical scientists to establish characterization strategies and support analytical method development, qualification, and validation activities
- Perform analytical characterization using techniques such as DLS, UV-Vis spectroscopy, HPLC/UHPLC, LC-MS, and other applicable analytical technologies
- Contribute to stability studies, technology transfer activities, and manufacturing readiness by generating scientifically sound data and recommendations
- Prepare and maintain technical documentation, including study protocols, technical reports, SOPs, electronic laboratory notebooks, and development summaries
- Ensure compliance with GMP, GLP where applicable, laboratory safety requirements, and data integrity principles
- Collaborate effectively with cross-functional teams to achieve project milestones
- Mentor junior laboratory colleagues when needed and contribute to continuous improvement initiatives
- Stay current with advances in nucleic acid delivery technologies, lipid nanoparticle formulation, analytical characterization, and pharmaceutical development
Benefits
- general: Annual performance bonus and additional financial benefits
- general: Comprehensive health package, including private health, life and accident insurance
- general: Wellbeing support for employees and their family members, including mental health consultations, health check-ups, vaccinations, and on-site health initiatives
- general: Opportunities for professional growth through internal training, access to Thermo Fisher e-University, and continuous development
- general: The opportunity to work in a global, innovation-driven organization and collaborate with international teams
- general: Daily benefits such as subsidized meals, gym access, and company transportation
- general: An inclusive and supportive culture, with team events and community initiatives
- general: 2 additional paid volunteering days per year
- general: Comprehensive health package, including private health, life and accident insurance
- general: Wellbeing support for employees and their family members, including mental health consultations, health check-ups, vaccinations, and on-site health initiatives
- general: Opportunities for professional growth through internal training, access to Thermo Fisher e-University, and continuous development
- general: The opportunity to work in a global, innovation-driven organization and collaborate with international teams
- general: Daily benefits such as subsidized meals, gym access, and company transportation
- general: An inclusive and supportive culture, with team events and community initiatives
- general: 2 additional paid volunteering days per year
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