Job DescriptionPosition SummaryVertex is entering an exciting phase of commercial diversification. As we expand into new pipeline disease areas and new geographies, we are investing in data, technology, and AI to scale commercial operations globally. The Commercial, Medical and External Affairs Technology team is expanding our capabilities with increased investment in data, platforms, and AI. This role establishes the end-to-end architecture required to scale AI and digital capabilities across the enterprise.The Senior Director, Commercialization Technology Architect is responsible for defining and governing target-state architectures, integration patterns, and platform standards that enable scalable, secure, and compliant AI solutions. This role ensures technologies deployed by Product, Data, and Engineering teams are aligned to enterprise architecture, interoperable across systems, and built for long-term scale. This is a technical architecture leadership role focused on translating business and product direction into production-ready system design, data flows, and platform integration.Key ResponsibilitiesArchitecture Strategy & StandardsDefine and maintain target-state architecture across Commercial and Medical ecosystemsEstablish reference architectures, design patterns, and engineering standards for AI-enabled systemsGovern architecture alignment across CRM, omnichannel, patient services, and enterprise platformsEnsure consistency with enterprise architecture and platform strategiesIntegration & Data ArchitectureOwn integration patterns and data flows across Salesforce, Veeva, data platforms, and downstream systemsDefine real-time and batch data architectures, including event-driven patterns and APIsEnsure alignment with enterprise data platforms (e.g., MDM, Snowflake, Databricks)Partner with Data teams to ensure data readiness, lineage, and interoperabilityTechnology & Platform GovernancePartners with engineering function and core technology to define standards across cloud and data platforms MDM, Snowflake, Databricks, Snowflake supporting Commercial and Medical affairs domainsLead architecture decisions for build vs. buy vs. partner solutionsEstablish environment, deployment, and DevOps architecture patterns within the Commercial and Medical affairs domainsMaintain architecture documentation for scalability, reuse, and audibilitySecurity, Risk & ComplianceEnsure architectures meet SOX, GxP, privacy, and security requirementsDefine patterns for observability, audibility, and controls in AI systemsPartner with InfoSec, Legal, Privacy, and Quality to embed compliance by designDelivery EnablementPartner with Product Management, Engineering, and Data teams to translate product requirements into executable architecturesProvide hands-on guidance to ensure solutions are production-ready and aligned to standardsServe as final architecture authority for design reviews and major platform decisionsKnowledge & SkillsDeep expertise in enterprise architecture, solution design, and distributed systemsStrong experience with CRM and commercial platforms (Salesforce, Veeva)Proven ability to design complex integrations and data architectures at scaleHands-on experience with cloud and data warehouse platforms (AWS, Azure, Snowflake, etc...) and modern data stacksExperience designing systems incorporating AI/ML and LLM-based capabilitiesStrong understanding of AI architectures (e.g. MCP)Expertise in security, compliance, and regulated environments (SOX, GxP)Ability to translate complex architecture into clear guidance for engineering teamsEducation & ExperienceBachelor’s or Master’s degree in Computer Science, Engineering, or related field12+ years of experience in enterprise architecture or solution architecture rolesExperience in pharma, biotech, or regulated healthcare environments strongly preferredProven track record delivering enterprise-scale platform and integration architectureExperience working across Commercial, Medical, or patient services systemsPay Range:$228,000 - $342,000Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.Flex Designation:Hybrid-Eligible Or On-Site EligibleFlex Eligibility Status:In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select2. On-Site: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company InformationVertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com