Job DescriptionGeneral/Position Summary The Director of FP&A, Value Architecture leads development and management of the value case for AI transformation initiatives, including the value hypothesis, financial model, KPIs, and measurement approach. The role partners with Digital, Technology and Engineering, Finance, Portfolio Strategy, functional leaders, and the CFO organization to ensure value cases are credible, operationally grounded, affordable, and measured consistently. This role provides the evidence base for portfolio-level value reporting and investment decisions, helping leaders understand value drivers, risks, opportunities, and business KPIs across the transformation portfolio. Key Duties & Responsibilities Value Case Development Define the value hypothesis, KPIs, and measurement approach for each initiative at initiation. Develop and maintain consistent value architecture standards, assumptions, definitions, and methods. Partner with functional leads and SMEs to ground value hypotheses in operational reality. Planning, Forecasting, and Business Partnership Connect initiative value cases to budget, forecast, and long-range planning processes. Analyze trends, risks, opportunities, and business KPIs to improve decision making and forecast accuracy. Develop analytics and reporting that communicate value drivers, affordability, and expected ROI. Value Realization Tracking Track projected versus realized value and maintain a clear portfolio view of value realization. Reconcile realized value with original investment theses and identify areas on track, at risk, or requiring revision. Provide evidence to Portfolio Strategy to inform sequencing, acceleration, and stop decisions. Financial Partnership, Controls, and Governance Partner with DTE on cost-to-run modeling and total cost of ownership. Partner with Finance on affordability analysis and investment governance inputs. Support close, accrual, and governance processes requiring documentation, control awareness, or SOX-compliant discipline. Portfolio Value Coordination Maintain an auditable record of value cases, KPIs, assumptions, and realization outcomes. Provide the evidence base for portfolio-level value reporting and future investment decisions. Direct and quality-control partner Value Architects embedded in delivery teams. Partner with HR and business leaders on headcount reporting, forecasting, and planning where workforce assumptions affect value or affordability. Required Education Level Bachelor's degree in finance, economics, engineering, strategy, or a related field required. Advanced degree, such as an MBA or master's degree in economics or analytics, preferred. Required Experience Typically requires 10 or more years of experience in value management, strategic finance, consulting, or business analytics, or equivalent education and experience. Experience building and tracking value cases for large-scale transformation or investment programs. Experience with affordability modeling, cost-to-run, total cost of ownership, and cross-functional initiative coordination. Pharmaceutical, biotech, or science-driven industry experience preferred. People management or team leadership experience required. Required Knowledge/Skills Expertise in value case development, benefits realization, investment appraisal, and financial modeling. Ability to define rigorous KPIs and measurement frameworks that are analytically sound and operationally practical. Strong analytical and critical thinking skills, including the ability to challenge assumptions and identify flawed logic. Excellent communication and data storytelling skills for senior and executive audiences. Strong collaboration and influence skills with Finance, DTE, functional leaders, and portfolio stakeholders. Expertise with Excel and PowerPoint required; knowledge of planning, BI, and visualization tools preferred. Continuous improvement mindset and ability to adapt as priorities, governance, and reporting needs evolve. #HYBRID#LI-MF1 Pay Range:$180,700 - $271,100Disclosure Statement:The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.Flex Designation:Hybrid-Eligible Or On-Site EligibleFlex Eligibility Status:In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select2. On-Site: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company InformationVertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com